~~~ This report is generated using bear v2.2.0 for R. ~~~ Authors: Hsin-ya Lee, Yung-jin Lee College of Pharmacy, Kaohsiung Medical University Kaohsiung, Taiwan 80708 E-mail: hsinyalee@gmail.com,pkpd.taiwan@gmail.com bear's website: http://pkpd.kmu.edu.tw/bear R website: http://www.r-project.org --------------------------------------------------- Statistical Summaries for Bioequivalence Study (N= 14 ) -------------------------------------------------------------------------- Parameters Test_Mean Test_SD Ref_Mean Ref_SD 1 Cmax 1662.536 181.868 1589.643 186.703 2 AUC0-t 13742.526 1945.507 13124.974 1994.792 3 AUC0-inf 14479.338 2230.335 13721.289 2068.855 4 ln(Cmax) 7.411 0.106 7.365 0.120 5 ln(AUC0-t) 9.519 0.143 9.470 0.163 6 ln(AUC0-inf) 9.570 0.152 9.515 0.161 Statistical Analysis -------------------------------------------------------------------------- Parameters CI90_lower Point_estimated CI90_upper 1 ln(Cmax) 100.312 104.765 109.416 2 ln(AUC0-t) 98.529 104.875 111.629 3 ln(AUC0-inf) 99.080 105.534 112.409 ------------------------------------------------------------------------- CI90: 90% confidence interval -------------------------------------------------------------------------- Summaries for Pharmacokinetic Analysis (NCA) Test Reference ------------------------------------------------------ Parameters Mean_T SD_T CV_T Mean_R SD_R CV_R 1 Cl/F 5.654 0.855 15.124 5.975 1.031 17.258 2 Lambda_z 0.134 0.015 11.386 0.136 0.007 5.173 3 Tmax 2.321 0.541 23.301 2.161 0.585 27.080 4 T1/2(z) 5.268 0.672 12.757 5.119 0.265 5.185 5 Vd/F 42.676 6.746 15.808 44.214 8.550 19.337 6 MRT0inf 8.200 0.824 10.054 8.027 0.397 4.951 7 AUCratio 95.053 1.811 1.905 95.634 0.685 0.717 ----------------------------------------------------- AUC ratio: (AUC0-t/AUC0-inf)*100 -----------------------------------------------------